Systemic sclerosis & Raynaud's
Clinical characteristics, predictors and prognosis of systemic sclerosis with scleroderma renal crisis and pulmonary arterial hypertension
Authors' conclusion
PAH may precede, follow, or coincide with SRC. Patients with both SRC and PAH had a significantly higher risk of GIB. Older age and elevated NT-proBNP were independent factors associated with the coexistence of SRC and PAH.
Study context
- Population
- Patients diagnosed with systemic sclerosis (SSc) at the authors' institute, January 2013 to April 2024
- Participants
- 234 patients
- Exposure
- SSc with both scleroderma renal crisis (SRC) and pulmonary arterial hypertension (PAH) vs PAH alone, SRC alone, and neither
- SRC + PAHn = 17
- Outcome
- Coexistence of PAH and SRC: clinical features, predictors and prognosis
Methodological detailssingle-centre, multivariate logistic regression
- Single-centre
- Multivariate logistic regression
Main finding
As reported in the abstract
Prevalence of both PAH and SRC
SRC + PAH
7.3%
17
- PAH preceded SRC
- 5
- PAH followed SRC
- 3
- PAH and SRC occurred simultaneously
- 9
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Predictor of coexistence of PAH and SRCvs SRC alone: GIBGIB, independently associated | 9.545 (1.679–54.264) | P = 0.011 | |
| Predictors of coexistence of PAH and SRC vs PAH alone: older age at onset and elevated NT-proBNPSRC + PAHvs PAH aloneOlder age at disease onset | 1.200 (1.014–1.420) | P = 0.033 | |
| Predictors of coexistence of PAH and SRC vs PAH alone: older age at onset and elevated NT-proBNPSRC + PAHvs PAH aloneElevated NT-proBNP | 1.001 (1.000–1.001) | P = 0.030 | |
| 0.050.21520Odds ratio (log scale) |
SRC + PAH vs SRC alone: clinical characteristics
- SRC + PAH had higher prevalence of ILD, higher rate of gastrointestinal bleeding (GIB) and lower serum albumin than SRC alone
Original publication
Clinical characteristics, predictors and prognosis of systemic sclerosis with scleroderma renal crisis and pulmonary arterial hypertension. Clin Exp Rheumatol. Published 5 January 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →