Systemic sclerosis & Raynaud's
Histogram-Based Densitometry Index to Assess the Severity of Interstitial Lung Disease in Systemic Sclerosis in Standard and Low-Dose Computed Tomography
Authors' conclusion
Thresholds for both standard and reduced CII to identify extensive ILD were developed and validated, with an additional association with mortality.
Study context
- Population
- Patients with SSc-ILD with standard and reduced computed tomography (CT) scans availablederivation: 157 CT scans, 119 patients
- Participants
- 243 patients
- Comparison
- Standard CT computerized integrated index (CII) vs reduced CT CII for extensive SSc-ILD
- Outcome
- Extensive ILD (Goh staging system)
Methodological detailsderivation and validation cohorts, generalized estimating equation regression, Kaplan-Meier analysis
- Derivation and validation cohorts
- Generalized estimating equation regression
- Kaplan-Meier analysis
Performance
As reported in the abstract
Association with extensive ILD
| Test or model | OR | AUC |
|---|---|---|
| Standard CII | 0.53 (95% CI 0.37-0.75) | 0.77 (95% CI 0.68-0.87) |
| Reduced CII | 0.54 (95% CI 0.35-0.82) | 0.78 (95% CI 0.70-0.87) |
OR
Standard CII0.53 (95% CI 0.37-0.75)
Reduced CII0.54 (95% CI 0.35-0.82)
AUC
Standard CII0.77 (95% CI 0.68-0.87)
Reduced CII0.78 (95% CI 0.70-0.87)
Further findings
Prediction of mortality
| OR (95% CI) | ||
|---|---|---|
| Extensive ILD (Goh staging) | 2.94 (1.10–7.82) | |
| Standard CII ≤ −0.96 | 1.78 (1.24–2.56) | |
| Reduced CII ≤ −1.85Marginal P value | 1.27 (0.93–1.75) | |
| 0.10.31310Odds ratio (log scale) |
Original publication
Histogram-Based Densitometry Index to Assess the Severity of Interstitial Lung Disease in Systemic Sclerosis in Standard and Low-Dose Computed Tomography. J Rheumatol. Published 1 February 2024. doi:10.
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