Systemic sclerosis & Raynaud's
High-resolution peripheral quantitative computed tomography for the assessment of acro-osteolysis and calcinosis in patients with systemic sclerosis
Authors' conclusion
HR-pQCT allowed precise and reliable classification and grading of acro-osteolysis and acral calcinosis.
Study context
- Population
- Patients with systemic sclerosis (SSc)
- Participants
- 40 patients
- Comparison
- High-resolution peripheral quantitative CT (HR-pQCT) vs conventional hand radiographs for acro-osteolysis and calcinosis
- Outcome
- Presence and degree of acro-osteolysis (AO) and calcinosis by semiquantitative grading scales
Methodological detailssemiquantitative grading scales
- Semiquantitative grading scales
Performance
As reported in the abstract
Classification of patients as having AO
| Test or model | Value | Sensitivity (CR as reference) | Specificity (CR as reference) | Sensitivity (HR-pQCT as reference) | Specificity (HR-pQCT as reference) |
|---|---|---|---|---|---|
| HR-pQCT | 18 events | 93% (95% CI: 66-99%) | 80% (95% CI: 59-93%) | ||
| CR | 14 events | 72% (95% CI: 47-90%) | 95% (95% CI: 76-99%) |
Value
HR-pQCT18 events
CR14 events
Sensitivity (CR as reference)
HR-pQCT93% (95% CI: 66-99%)
CR— not stated in the abstract
Specificity (CR as reference)
HR-pQCT80% (95% CI: 59-93%)
CR— not stated in the abstract
Sensitivity (HR-pQCT as reference)
HR-pQCT— not stated in the abstract
CR72% (95% CI: 47-90%)
Specificity (HR-pQCT as reference)
HR-pQCT— not stated in the abstract
CR95% (95% CI: 76-99%)
Further findings
| Outcome | Values | P value |
|---|---|---|
| Calcinosis grade by HR-pQCT, patients with vs without AO | AO median 2 (IQR 1–3) · No AO median 0 (IQR 0–1) | P < 0.01 |
| Grade 3 calcinosis changes | AO 42.9% |
- Grade 3 calcinosis changes: n=6/14
Grade 3 calcinosis changes
- Observed exclusively in patients with acro-osteolysis (AO)
Test-retest reliability of HR-pQCT for AO and calcinosis
- Moderate to excellent test-retest reliability
Original publication
High-resolution peripheral quantitative computed tomography for the assessment of acro-osteolysis and calcinosis in patients with systemic sclerosis. Joint Bone Spine. Published 1 February 2024. doi:10.
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