Systemic sclerosis & Raynaud's
Lung ultrasound versus high-resolution computed tomography in the longitudinal monitoring of interstitial lung disease: a prospective cohort study in systemic sclerosis
Authors' conclusion
LUS, as a non-invasive, repeatable tool, shows clinically relevant potential for identifying radiographic progression or improvement in SSc-associated ILD (SSc-ILD).
Study context
- Population
- Patients with systemic sclerosis (SSc)83 completed follow-up
- Participants
- 131 patients
- Exposure
- Lung ultrasound (LUS) vs high-resolution computed tomography (HRCT) for monitoring SSc-ILD change
- Outcome
- Agreement of LUS with HRCT ILD extent
Methodological detailssingle-centre, longitudinal
- Single-centre
- Longitudinal
Main finding
As reported in the abstract
- Baseline LUS score vs interstitial lung disease (ILD) extent on HRCT, Spearman's Rho
- 0.9087, P < 0.0001
- ΔLUS vs ΔHRCT, Spearman's Rho
- 0.9046, P < 0.001
- ΔLUS as predictor of ΔHRCT, β
- 0.535, P < 0.001
- ΔLUS as predictor of ILD progression, OR
- 1.874, P = 0.003
- ΔLUS as predictor of ILD improvement, OR
- 0.821, P < 0.001
- LUS score increase >5 points predicting ILD progression, AUC
- 0.98
- LUS score decrease >4 points predicting ILD improvement, AUC
- 0.94
Observational data: associations, not effects.
Original publication
Lung ultrasound versus high-resolution computed tomography in the longitudinal monitoring of interstitial lung disease: a prospective cohort study in systemic sclerosis. Semin Arthritis Rheum. Published 26 August 2026. doi:10.
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