Systemic sclerosis & Raynaud's
Radiomic analysis of high-resolution computed tomography predicts interstitial lung disease progression and mortality in systemic sclerosis
Authors' conclusion
The PVV% and the extent of honeycombing independently predict mortality and ILD progression, respectively.
Study context
- Population
- SSc-ILD patients with baseline and follow-up high-resolution CT (HRCT) scans267 (85%) in mortality analysis
- Participants
- 313 patients
- Outcome
- All-cause mortality and ILD progression predicted by HRCT-derived radiomic features
Methodological detailsradiomic prognostic analysis, automated lung texture analysis (LTA, Imbio), univariable and multivariable Cox regression, generalized estimating equation models
- Radiomic prognostic analysis
- Automated lung texture analysis (LTA, Imbio)
- Univariable and multivariable Cox regression
- Generalized estimating equation models
Main finding
As reported in the abstract
- Deaths over 42 (IQR 27-110) months of follow-up
- 65 (24%)
- Pulmonary vessel volume (PVV)% independently predicted mortality, adjusted HR
- 1.21 (1.094-1.354) (95% CI)
- PVV% in upper zones and mortality, adjusted HR
- 1.28 (1.11-1.46) (95% CI)
- Whole-lung honeycombing, only independent radiomic predictor of interstitial lung disease (ILD) progression, aOR
- 1.53 (1.17-2.01) (95% CI)
- ILD progression episodes among 261 yearly follow-up visits from 160 patients
- 99 (37.7%)
- Patients with at least one episode of ILD progression
- 50.6%
Observational data: associations, not effects.
Original publication
Radiomic analysis of high-resolution computed tomography predicts interstitial lung disease progression and mortality in systemic sclerosis. Rheumatology (Oxford). Published 27 August 2026. doi:10.
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