Systemic sclerosis & Raynaud's
Lung ultrasound and high-resolution computed tomography quantitative variations during nintedanib treatment for systemic sclerosis-associated interstitial lung disease
Authors' conclusion
We present preliminary results on NIN effects on SSc-ILD as assessed by LUS, a useful method for frequently repeated monitoring, and CALIPER, a valid implementation whenever a HRCT is performed.
Study context
- Population
- SSc-ILD patients who started NIN (70% female, mean age 62 years)
- Participants
- 10 patients
- Outcome
- LUS (B-lines, pleural line irregularities) and quantitative high-resolution CT (HRCT) (CALIPER) changes during NIN treatment
- Follow-up
- 12 months
Methodological detailssingle-group, 12-month follow-up
- Single-group
- 12-month follow-up
Main finding
As reported in the abstract
LUS: mean total number of BL and PLI
- B-lines (BL), baseline to 12 months: 175.1 [66.7] to 120.8 [70.3]
- P = 0.005
- Pleural line irregularities (PLI), baseline to 12 months: 50.6 [32.5] to 37.2 [22.4]
- P = 0.05
Observational data: associations, not effects.
Further findings
Predictors of worse lung ultrasound (LUS) outcomes
- Male gender, smoking habit and baseline FVC <70% predicted associated with worse LUS outcomes
Greater BL and PLI reduction in PROM improvers: mMRC dyspnoea scale
- BL
- P = 0.016
- PLI
- P = 0.04
Greater BL and PLI reduction in PROM improvers: Saint George's Respiratory Questionnaire
- BL
- P = 0.006
- PLI
- P = 0.026
Pulmonary function tests · 12 months
- Stabilization
Original publication
Lung ultrasound and high-resolution computed tomography quantitative variations during nintedanib treatment for systemic sclerosis-associated interstitial lung disease. Rheumatology (Oxford). Published 4 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →