Systemic sclerosis & Raynaud's
Correlation between angiotensin-converting-enzyme 2 gene polymorphisms and systemic sclerosis
Authors' conclusion
Polymorphisms of ACE2 may account for the development of AH and CVS disorders in SSc patients.
Study context
- Population
- Patients with systemic sclerosis (SSc)60 women · 21 men
- Participants
- 81 patients
- Comparison
- Carriers vs non-carriers of ACE2 polymorphisms
- Outcome
- Associations of ACE2 polymorphisms rs879922, rs2285666 and rs1978124 with the development of SSc
Methodological detailsGenotyping by restriction-fragment-length polymorphism (rs1978124) and TaqMan SNP Genotyping Assay (rs879922, rs2285666); serum ACE2 by ELISA
- Genotyping by restriction-fragment-length polymorphism (rs1978124) and TaqMan SNP Genotyping Assay (rs879922, rs2285666); serum ACE2 by ELISA
Main finding
As reported in the abstract
Associations of ACE2 polymorphisms with SSc features
- Allele C of rs879922: greater risk of arterial hypertension, OR
- 2.5
- Allele C of rs879922: P for arterial hypertension
- p=0.018
- Allele A of rs2285666: lower risk of any CVD, RR
- 0.4
- Allele A of rs2285666: P for any CVD
- p=0.051
Original publication
Correlation between angiotensin-converting-enzyme 2 gene polymorphisms and systemic sclerosis. Clin Exp Rheumatol. Published 27 February 2023. doi:10.
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