Systemic sclerosis & Raynaud's
Early initiation of angiotensin-converting enzyme inhibitor in patients with scleroderma renal crisis: a nationwide inpatient database study
Main finding · In-hospital mortality or haemodialysis dependence at dischargeResult — go to the resultOdds ratio 0.69 95% CI 0.48–1.00Authors' conclusion
The present study showed that early initiation of ACEi was associated with lower composite outcome of in-hospital mortality or haemodialysis dependence at discharge in patients with SRC.
Study context
- Population
- Hospitalized patients with scleroderma renal crisis, nationwide inpatient database, Japan, July 2010–March 2020
- Participants
- 475 patients
- Exposure
- Angiotensin-converting enzyme inhibitor (ACEi) within 2 days of admission vs no early ACEi
- Early ACEin = 248
- Controln = 227reference
- Outcome
- Composite of:
- In-hospital mortality
- Haemodialysis dependence at discharge
- Follow-up
- Discharge
Methodological detailsnationwide inpatient database, propensity-score overlap weighting
- Nationwide inpatient database
- Propensity-score overlap weighting
Main finding
As reported in the abstract
In-hospital mortality or haemodialysis dependence at discharge
Odds ratio
0.69
95% CI 0.48–1.00
P = 0.049
By group
Early ACEivs Control
OR 0.69 (95% CI 0.48–1.00); P = 0.049
Observational data: associations, not effects.
Original publication
Early initiation of angiotensin-converting enzyme inhibitor in patients with scleroderma renal crisis: a nationwide inpatient database study. Rheumatology (Oxford). Published 17 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →