Systemic sclerosis & Raynaud's
Microvascular damage in autoimmune connective tissue diseases: a capillaroscopic analysis from 20 years of experience in a EULAR training and research referral centre for imaging
Authors' conclusion
This large size sample of patients with CTDs, collected over 20 years of analysis, confirms the highest prevalence of specific capillaroscopic alterations in patients with SSc, DM and MCTD, when compared with other CTDs.
Study context
- Population
- Patients with Raynaud's phenomenon secondary to a CTD at first single nailfold videocapillaroscopy (NVC), 2001–2021
- Participants
- 1,181 patients
- Exposure
- Capillaroscopic findings across connective tissue diseases (CTDs)
- Outcome
- Prevalence of morphological capillary findings on NVC (scleroderma and non-scleroderma patterns)
- Follow-up
- First single NVC
Methodological detailssingle-centre, EULAR referral centre
- Single-centre
- EULAR referral centre
Main finding
As reported in the abstract
Giant capillaries
P < 0.001 when comparing each rate vs the other CTDs
Observational data: associations, not effects.
Further findings
| Outcome | Values | P value |
|---|---|---|
| Mean capillary countSSc, DM, MCTD (each) vs other CTDs · significantly lower | SSc mean 7.04 ± 0.18 capillaries/linear mm · DM mean 6.5 ± 0.75 capillaries/linear mm · MCTD mean 7.7 ± 2 capillaries/linear mm | P < 0.001 for each rate vs the other CTDs |
| Non-specific abnormalities of capillary morphologySSc, MCTD, aPS (each) vs other CTDs · significantly more frequent | SSc 48% · MCTD 41% · aPS 36% | all p<0.001 vs each other CTDs |
Original publication
Microvascular damage in autoimmune connective tissue diseases: a capillaroscopic analysis from 20 years of experience in a EULAR training and research referral centre for imaging. RMD Open. Published 14 July 2023. doi:10.
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