Systemic sclerosis & Raynaud's
Steroid hormones in systemic sclerosis: associations with disease characteristics and modifications during scleroderma renal crisis
Authors' conclusion
RAAS and GC hormones are abnormally produced in SSc patients, especially in patients with severe SSc and during SRC.
Study context
- Population
- Patients with systemic sclerosis (SSc) and healthy controls
- Participants
- 122 vs 52
- Exposure
- SSc patients vs healthy controls
- SScn = 122
- Healthy controlsn = 52reference
- Outcome
- Serum RAAS hormones (renin, aldosterone and precursors) and GC hormones (cortisol, cortisone, 11-deoxycortisol, 18-OH-F)
Methodological detailscase-control comparison with healthy controls
- Case-control comparison with healthy controls
Main finding
As reported in the abstract
- SSc patients had significantly lower aldosterone levels (although within normal range) than controls
- Similar renin levels in SSc patients and controls
- Higher B levels in SSc patients than controls
- Higher cortisol, 11-desoxycortisol and 18-OH-F levels in SSc patients than controls
- Lower cortisone levels in SSc patients than controls
Observational data: associations, not effects.
Further findings
Association of abnormal renin-angiotensin-aldosterone system (RAAS) hormone levels with disease characteristics
- Abnormal RAAS hormone levels associated with more severe SSc phenotype (lung and skin fibrosis, heart and pulmonary vascular involvements, inflammation)
RAAS hormones before and during scleroderma renal crisis (5 patients)
- Concentrations varied considerably between patients, but consistently included normal/increased aldosterone and elevated renin levels
Original publication
Steroid hormones in systemic sclerosis: associations with disease characteristics and modifications during scleroderma renal crisis. Rheumatology (Oxford). Published 23 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →