Systemic sclerosis & Raynaud's
Prevalence and Characteristics of Patients With Systemic Sclerosis Fulfilling the 2019 EULAR/American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus
Authors' conclusion
Ten percent of patients with SSc fulfill the 2019 EULAR/ACR classification criteria for SLE. These patients comprise a distinct demographic, serologic, and clinical phenotype but have similar severe SSc-specific end-organ damage and mortality as patients with SSc alone.
Study context
- Population
- Previously described single-center cohort of patients with systemic sclerosis (SSc)analysed
- Participants
- 402 participants
- Exposure
- SSc-SLE vs SSc alone
- SSc-SLEn = 40
- Outcome
- Fulfillment of the 2019 EULAR/ACR classification criteria for SLE (prevalence of SSc-SLE)
Methodological detailssingle-center
- Single-center
Main finding
As reported in the abstract
Prevalence of SSc-SLE (fulfilling 2019 EULAR/ACR SLE criteria)
SSc-SLE
10%
40
Observational data: associations, not effects.
Further findings
Initial SLE diagnosis purported
P < 0.001
Anti-U1-RNP antibody positivity prevalence
P < 0.001
Death during follow-up · no difference in survival
P = 0.404
Demographics and disease subtype
- SSc-SLE more likely female, African American, and with limited cutaneous SSc
- Neuropsychiatric and renal involvement were rare
Original publication
Prevalence and Characteristics of Patients With Systemic Sclerosis Fulfilling the 2019 EULAR/American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus. Arthritis Care Res (Hoboken). Published 19 December 2023. doi:10.
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