Systemic sclerosis & Raynaud's
A Prospective Observational Study of Disease Severity and Mortality in Hispanic American Patients With Systemic Sclerosis
Main finding · FVC % predicted (longitudinal)Result — go to the resultPoint estimate −9.3%Authors' conclusion
Hispanic patients have higher likelihood of having U1-RNP positivity and SLE overlap, more severe restrictive lung disease, as well as higher rate of mortality than non-Hispanic White patients.
Study context
- Population
- Patients fulfilling systemic sclerosis (SSc) classification criteria with disease duration <5 years at enrollment, Genetics versus Environment in Scleroderma Outcome Study cohort
- Participants
- 427 patients
- Exposure
- Hispanic vs non-Hispanic White and non-Hispanic Black patients with SSc
- Hispanicn = 124
- Non-Hispanic Whiten = 220reference
- Non-Hispanic Blackn = 83
- Outcome
- Disease manifestations of Hispanic vs non-Hispanic White and Black patients with SSc
Methodological detailslongitudinal
- Longitudinal
Main finding
FVC % predicted (longitudinal)
Point estimate
−9.3%
P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Point estimate | P value |
|---|---|---|
| mRSS (longitudinal)Hispanic vs Non-Hispanic Black | −3.2 | P = 0.029 |
| Perceived functional disability scores (serial)Hispanic vs Non-Hispanic White | 0.29 | P < 0.001 |
mRSS (longitudinal)
- Similar mRSS in Hispanic and non-Hispanic White patients
Mortality
- Higher mortality rates in Hispanic than White patients, even after adjustment for age, gender and socioeconomic status
Baseline characteristics · enrollment
- vs non-Hispanic White: Hispanic patients younger, longer disease duration, more U1-RNP positivity and concurrent systemic lupus erythematosus (SLE), lower income and education
- vs non-Hispanic Black: Hispanic patients more often limited cutaneous involvement and anticentromere antibodies
Original publication
A Prospective Observational Study of Disease Severity and Mortality in Hispanic American Patients With Systemic Sclerosis. Arthritis Care Res (Hoboken). Published 25 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →