Systemic sclerosis & Raynaud's
Patients with systemic sclerosis and low CD4 numbers after autologous stem cell transplantation have a favorable outcome
Authors' conclusion
Taken together, this study supports the theory that a profound CD4 + T cell and B cell lymphopenia is important for patients with SSc to achieve a sustained response after aHSCT.
Study context
- Population
- Patients with severe systemic sclerosis (SSc) who underwent autologous hematopoietic stem cell transplantation (aHSCT), Tübingen, Germany
- Participants
- 32 patients
- Exposure
- Responders vs non-responders after aHSCT
- Outcome
- Lymphocyte subsets after aHSCT, responders vs non-responders
Methodological detailsmonocentric
- Monocentric
Main finding
As reported in the abstract
- Responders had significantly lower CD4+ T cells (month 1 and 3), B cells (month 3 and 6) and natural killer cells (month 1) after aHSCT
- Lower CD4+ T cells and natural killer cells at 1 month and B cells at 3 months: higher probability of being a responder (Mantel-cox test, significant deviation of probability curves)
Observational data: associations, not effects.
Original publication
Patients with systemic sclerosis and low CD4 numbers after autologous stem cell transplantation have a favorable outcome. Arthritis Res Ther. Published 20 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →