Systemic sclerosis & Raynaud's
Factors associated with physical function among people with systemic sclerosis: a SPIN cohort cross-sectional study
Authors' conclusion
Physical function is impaired for many individuals with SSc and is associated with multiple disease factors.
Study context
- Population
- Scleroderma Patient-centered Intervention Network Cohort participants with systemic sclerosis (SSc)
- Participants
- 2,385 participants
- Exposure
- SSc participants vs US general population normative data
- Outcome
- Physical function T-score (PROMIS Version 2 Physical Function domain) at enrolment
- Follow-up
- Enrolment
Methodological detailsSPIN cohort, multivariable linear regression
- SPIN cohort
- Multivariable linear regression
Main finding
As reported in the abstract
Physical function T-score (PROMIS)
Mean physical function T-score, SSc (SD 8.9); ≈2/3 SD below US general population (mean 50, SD 10)
43.7
Observational data: associations, not effects.
Further findings
Factors associated with physical function (multivariable analysis; points, 95% CI)
- Older age, per SD years
- −0.74 (95% CI −0.78 to −1.08)
- Female sex (−2.37 to −0.34)
- −1.35
- Fewer years of education, per SD (−0.75 to −0.07)
- −0.41
- Single, divorced or widowed (−1.48 to −0.03)
- −0.76
- Smoking (−4.42 to −1.85)
- −3.14
- Alcohol consumption, per SD drinks/week (0.45-1.14)
- 0.79
- BMI, per SD (−1.75 to −1.07)
- −1.41
- Diffuse subtype (−2.23 to −0.62)
- −1.43
- Gastrointestinal involvement (−3.53 to −1.62)
- −2.58
- Digital ulcers (−2.94 to −0.98)
- −1.96
- Moderate small joint contractures (−2.94 to −0.93)
- −1.94
- Severe small joint contractures (−3.24 to −0.28)
- −1.76
- Moderate large joint contractures (−3.44 to −0.76)
- −2.10
- Severe large joint contractures (−4.64 to −0.44)
- −2.54
- ILD (−2.27 to −0.77)
- −1.52
- PAH (−4.91 to −2.52)
- −3.72
- RA (−3.64 to −0.56)
- −2.10
- IIM (−3.63 to −0.56)
- −2.10
Original publication
Factors associated with physical function among people with systemic sclerosis: a SPIN cohort cross-sectional study. Rheumatology (Oxford). Published 12 March 2024. doi:10.
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