Systemic sclerosis & Raynaud's
Anxiety symptoms and associated factors in the Scleroderma Patient-centered Intervention Network (SPIN) cohort: a cross-sectional study
Authors' conclusion
Anxiety symptoms were somewhat elevated among individuals with SSc and associated with multiple sociodemographic and disease factors.
Study context
- Population
- Multinational SPIN Cohort participants with SSc, assessed at enrolment
- Participants
- 2,463 participants
- Exposure
- SSc cohort vs Patient-Reported Outcomes Measurement Information System (PROMIS) US general population normative sample
- SScn = 2,463
- Outcome
- Anxiety symptoms, PROMIS v2 4a Anxiety T-score (mean = 50, SD = 10 in US normative sample)
- Follow-up
- Enrolment
Methodological detailsmultinational cohort, multivariable linear regression
- Multinational cohort
- Multivariable linear regression
Main finding
As reported in the abstract
PROMIS Anxiety T-score
| Group | Value | 95% CI |
|---|---|---|
| SSc | mean 52.6 (SD 10.0) | 52.2, 53.0 |
| US general population | mean 50 (SD 10) |
Value
SScmean 52.6 (SD 10.0)
US general populationmean 50 (SD 10)
95% CI
SSc52.2, 53.0
US general population— not stated in the abstract
Observational data: associations, not effects.
Further findings
Factors associated with higher anxiety T-score in SSc (multivariable linear regression)
- Younger age
- 1.07 (T-score points per 10 years; 95% CI 0.74, 1.40)
- Female sex
- 1.81 (95% CI 0.63, 3.00)
- Non-married status
- 0.99 (95% CI 0.14, 1.84)
- Race or ethnicity other than White
- 1.79 (95% CI 0.72, 2.85)
- Living in Canada vs US
- 1.70 (95% CI 0.61, 2.79)
- Living in UK vs US
- 1.53 (95% CI 0.06, 2.99)
- Living in France vs US
- 2.01 (95% CI 0.98, 3.03)
- Higher BMI
- 0.11 (95% CI 0.03, 0.17)
- Less time since non-Raynaud's symptom onset
- 0.82 (per 10 years; 95% CI 0.40, 1.30)
- Gastrointestinal involvement
- 2.70 (95% CI 1.52, 3.88)
- Moderate small joint contractures
- 1.24 (95% CI 0.10, 2.38)
- Absence of ILD
- 0.93 (95% CI −1.79, −0.07)
- Sjögren disease
- 1.67 (95% CI 0.17, 3.17)
- ILD not statistically significant when accounting for an interaction with country
- Anxiety also associated with pruritus and pain intensity in a sensitivity analysis
Original publication
Anxiety symptoms and associated factors in the Scleroderma Patient-centered Intervention Network (SPIN) cohort: a cross-sectional study. Rheumatology (Oxford). Published 13 August 2025. doi:10.
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