Systemic sclerosis & Raynaud's
Minimal Detectable Changes of the Health Assessment Questionnaire–Disability Index, Patient‐Reported Outcomes Measurement Information System‐29 Profile Version 2.0 Domains, and Patient Health Questionnaire‐8 in People With Systemic Sclerosis: A Scleroderma Patient‐Centered Intervention Network Cohort Cross‐Sectional Study
Authors' conclusion
MDC95 and MDC90 estimates were precise and similar across age, sex, and SSc subtype groups.
Study context
- Population
- Scleroderma Patient-Centered Intervention Network Cohort participants with systemic sclerosis (SSc), baseline assessments April 2014 to August 2023 (mean age 54.9 years; 87% female; 38% diffuse SSc)
- Participants
- 2,571 participants
- Exposure
- MDC estimates compared by age, sex and SSc subtype
- Outcome
- MDC95 and MDC90 of the HAQ-DI, PROMIS-29v2.0 domains and PHQ-8
Methodological detailscohort (SPIN Cohort) baseline assessments, percentile bootstrapping (1,000 resamples)
- Cohort (SPIN Cohort) baseline assessments
- Percentile bootstrapping (1,000 resamples)
Main finding
As reported in the abstract
MDC95
Health Assessment Questionnaire-Disability Index (HAQ-DI) MDC95
0.41 points
95% CI 0.40–0.42
PROMIS-29v2.0 seven domains MDC95, lowest
4.88 points
95% CI 4.72–5.05
PROMIS-29v2.0 seven domains MDC95, highest
9.02 points
95% CI 8.80–9.23
PHQ-8 MDC95
5.16 points
95% CI 5.06–5.26
Observational data: associations, not effects.
Further findings
MDC95 across age, sex and SSc subtype subgroups
- MDC95 estimates were not materially different across subgroups
Original publication
Minimal Detectable Changes of the Health Assessment Questionnaire–Disability Index, Patient‐Reported Outcomes Measurement Information System‐29 Profile Version 2.0 Domains, and Patient Health Questionnaire‐8 in People With Systemic Sclerosis: A Scleroderma Patient‐Centered Intervention Network Cohort Cross‐Sectional Study. Arthritis Care Res (Hoboken). Published 27 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →