Systemic sclerosis & Raynaud's
Toll‐Like Receptor 8 is Expressed in Monocytes in Contrast to Plasmacytoid Dendritic Cells and Mediates Aberrant Interleukin‐10 Responses in Patients With Systemic Sclerosis
Authors' conclusion
TLR8 protein is not expressed in pDCs of patients with SSc. Accordingly, they do not respond to TLR8 stimulation. In contrast, monocytes of patients with SSc respond to TLR8 stimulation with increased IL-10 responses.
Study context
- Population
- Patients with systemic sclerosis (SSc), patients with pSS and healthy controls; monocytes, conventional dendritic cells (cDCs) and plasmacytoid dendritic cells (pDCs) from blood and skin
- Participants
- 16 / 10 / 13
- Comparison
- SSc vs pSS vs healthy controls
- SScn = 16
- pSSn = 10
- Healthy controls (HCs)n = 13reference
- Outcome
- TLR8 expression and function in immune cell subsets
Main finding
As reported in the abstract
- In all individuals, TLR8 expressed in monocytes and cDCs but not in pDCs
- TLR8 expression levels overall similar in SSc, pSS and HCs
- In all participants, TLR8 stimulation of pDCs did not induce IFN-I expression
- SSc vs HCs: P = 0.0126
- SSc vs HCs: P = 0.0170
Original publication
Toll‐Like Receptor 8 is Expressed in Monocytes in Contrast to Plasmacytoid Dendritic Cells and Mediates Aberrant Interleukin‐10 Responses in Patients With Systemic Sclerosis. Arthritis Rheumatol. Published 27 August 2024. doi:10.
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