Systemic sclerosis & Raynaud's
Nuclear Receptor Subfamily 4A Signaling as a Key Disease Pathway of CD1c + Dendritic Cell Dysregulation in Systemic Sclerosis
Authors' conclusion
NR4A1, NR4A2, and NR4A3 are important regulators of immunosuppressive and fibrosis-associated pathways in SSc cDCs.
Study context
- Population
- Peripheral blood CD1c+ conventional dendritic cell (cDCs) (CD1c+ cDCs (cDC2s)) from patients with systemic sclerosis (SSc) and healthy donors
- Participants
- 48 vs 12
- Comparison
- Patients with SSc vs healthy donors
- SScn = 48
- Healthy donorsn = 12reference
- Outcome
- Key disease pathways driving cDC alterations in SSc
Methodological detailstranscriptomic profiling, weighted gene correlation network analysis, chromatin immunoprecipitation (ChIP) sequencing, in vitro functional assays
- Transcriptomic profiling
- Weighted gene correlation network analysis
- ChIP sequencing
- In vitro functional assays
Main finding
As reported in the abstract
- Modules of coexpressed genes in cDCs correlated with SSc subtypes and key clinical traits (autoantibodies, skin score, ILD)
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Original publication
Nuclear Receptor Subfamily 4A Signaling as a Key Disease Pathway of CD1c + Dendritic Cell Dysregulation in Systemic Sclerosis. Arthritis Rheumatol. Published 8 December 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →