Systemic sclerosis & Raynaud's
Distinct Systemic Sclerosis Phenotypes Related to Ethnicity: An Opportunity to Personalize Care?
Authors' conclusion
Ethnicity was associated with distinct SSc phenotypes.
Study context
- Population
- Participants with systemic sclerosis (SSc) enrolled in the Canadian Scleroderma Research Group cohort who self-identified to a single ethnicity group
- Participants
- 1,477 eligible participants
- Exposure
- SSc characteristics compared across self-identified ethnic groups
- Whiten = 1,345
- Indigenousn = 55
- East/Southeast Asiann = 22
- Middle Easternn = 20
- Blackn = 16
- South Asiann = 12
- Latin Americann = 7
- Outcome
- Demographic, clinical and serological characteristics of SSc by ethnic background
Methodological detailsCanadian Scleroderma Research Group cohort, Kaplan-Meier curves and Cox regression for mortality
- Canadian Scleroderma Research Group cohort
- Kaplan-Meier curves and Cox regression for mortality
Main finding
As reported in the abstract
SSc phenotype by ethnicity
- Diffuse cutaneous SSc, White vs other ethnicities
- 33% vs 53%
- Telangiectasias, White vs other ethnicities
- 44% vs 67%
- Myositis, Black vs comparison
- 44% vs 10%
- Mean modified Rodnan skin score, Black vs comparison
- 18.4 vs 9.6
- Mean FVC, Black vs comparison
- 73.7% predicted vs 92.9% predicted
- DLco, Black vs comparison
- 54.5% predicted vs 70.6% predicted
- Anti-RNA polymerase III antibodies, Indigenous (highest prevalence) vs comparison
- 34% vs 19%
- Raynaud phenomenon, East/Southeast Asian (least frequent)
- 90%
- Digital ulcers, East/Southeast Asian (least frequent)
- 29%
Observational data: associations, not effects.
Further findings
Survival probability, Black individuals (lowest) · 1 and 5 years
- Survival at one year, Black
- 85%
- Survival at five years, Black
- 57%
Original publication
Distinct Systemic Sclerosis Phenotypes Related to Ethnicity: An Opportunity to Personalize Care? Arthritis Care Res (Hoboken). Published 1 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →