Systemic sclerosis & Raynaud's
Characteristics of Overlap Syndrome in a Large Cohort of Brazilian Patients With Systemic Sclerosis: A Retrospective Analysis
Authors' conclusion
Overall, Brazilian patients with SSc with OS have distinct clinical characteristics but do not have a worse prognosis compared to those without OS.
Study context
- Population
- Patients with systemic sclerosis (SSc) (2013 ACR/EULAR criteria), tertiary university hospital in Brazil
- Participants
- 787 patients
- Exposure
- SSc with overlap syndrome vs SSc without overlap syndrome
- Overlap syndrome (OS)n = 91
- Outcome
- Characteristics of SSc patients with OS vs without OS; factors associated with OS
Methodological detailssingle-centre (tertiary university hospital), univariate and multivariate analysis
- Single-centre (tertiary university hospital)
- Univariate and multivariate analysis
Main finding
As reported in the abstract
OS
11.6%
91
- OS
- OR (limited SSc, multivariate) 3.1
- OS
- OR (neoplasia, multivariate) 3.4
- OS
- OR (GC use, multivariate) 8.2
- OS
- OR (LEF use, multivariate) 5.5
- OS: earlier age at onset
- P = 0.004
- OS: earlier age at diagnosis
- P = 0.003
- OS: higher prevalence of limited SSc
- P for trend = 0.06
- OS: higher prevalence of musculoskeletal symptoms
- P < 0.001
- OS: higher prevalence of neoplasia
- P = 0.03
- OS: higher prevalence of sicca symptoms
- P < 0.001
- OS: lower frequency of pulmonary hypertension
- P = 0.048
- OS: lower frequency of diabetes mellitus
- P = 0.02
- OS: lower frequency of dyslipidemia
- P = 0.02
- OS: higher prevalence of anti-Ro
- P = 0.007
- OS: lower prevalence of anti-Scl70
- P = 0.003
- OS: more frequently prescribed glucocorticoids (GCs)
- P < 0.001
- OS: more frequently prescribed MTX
- P = 0.01
- OS: more frequently prescribed LEF
- P = 0.001
Observational data: associations, not effects.
Original publication
Characteristics of Overlap Syndrome in a Large Cohort of Brazilian Patients With Systemic Sclerosis: A Retrospective Analysis. J Rheumatol. Published 15 February 2025. doi:10.
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