Systemic sclerosis & Raynaud's
Risk stratifying systemic sclerosis–related pulmonary hypertension by left atrial strain
Authors' conclusion
Of the three LA GLS clusters, Cluster 3 had the shortest median survival.
Study context
- Population
- Patients with SSc-related pulmonary hypertension confirmed on right heart catheterization
- Participants
- 124 patients
- Exposure
- Left atrial (LA) global longitudinal strain (GLS) clusters 2 and 3 vs Cluster 1
- Cluster 1n = 40reference
- Cluster 2n = 34
- Cluster 3n = 50
- Outcome
- All-cause mortality
Methodological detailsexploratory, single-centre, k-means clustering, Kaplan-Meier and Cox proportional hazards model
- Exploratory
- Single-centre
- K-means clustering
- Kaplan-Meier and Cox proportional hazards model
Main finding
As reported in the abstract
Each group vs cluster 1Adjusted hazard ratio (95% CI)
Cluster 2
1.46(0.71–2.97)
Cluster 3
2.57(1.32–5.02)
- Survival difference between clusters
- log-rank P = 0.005
Observational data: associations, not effects.
Original publication
Risk stratifying systemic sclerosis–related pulmonary hypertension by left atrial strain. Rheumatology (Oxford). Published 30 January 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →