Systemic sclerosis & Raynaud's
Native myocardial T1 and right ventricular size by cardiovascular magnetic resonance (CMR) predict outcome in systemic sclerosis-associated pulmonary hypertension
Authors' conclusion
We identified prognostically relevant CMR metrics and thresholds for patients with SSc-PH.
Study context
- Population
- SSc-PH confirmed by right heart catheterization, clinically indicated CMR incl. native myocardial T1 and T2 mapping, 2016–2023
- Participants
- 148 participants
- Exposure
- CMR metrics as predictors of all-cause mortality
- Outcome
- All-cause mortality
Methodological detailssingle-centre, observational
- Single-centre
- Observational
Main finding
As reported in the abstract
Independent predictors of all-cause mortality · median 3.5 years follow-up
- RVESVi independent predictor, adjusted for age
- P = 0.0023
- Native T1 independent predictor, adjusted for age
- P = 0.0024
- RVESVi independent predictor, adjusted for age and PH subtype
- P < 0.001
- Native T1 independent predictor, adjusted for age and PH subtype
- P = 0.0056
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Characteristics of patients who died vs survivors65 vs 60 years | P = 0.035 |
- Characteristics of patients who died vs survivors — More dilated RV in patients who died
- P < 0.001
- Characteristics of patients who died vs survivors — More hypertrophied RV in patients who died
- P = 0.013
- Characteristics of patients who died vs survivors — More impaired RV in patients who died
- P < 0.001
- Characteristics of patients who died vs survivors — More dilated right atria in patients who died
- P = 0.043
- Characteristics of patients who died vs survivors — Higher native myocardial T1 in patients who died
- P < 0.001
Mortality · median 3.5 years (range 0.1-7.3)
- Patients died during follow-up
- 66 (45%)
Optimal prognostic thresholds
- RVESVi threshold
- ≤38 mL/m²
- Native T1 threshold
- ≤1119 ms
- Thresholds prognostic
- P < 0.001
Survival by combined RVESVi and native T1 thresholds
- RVESVi ≤ 38 mL/m² and native T1 ≤ 1119 ms: significantly better outcomes than all other combinations
- P < 0.001
- RVESVi > 38mL/m² and native T1 ≤ 1119 ms: significantly better survival than RVESVi > 38mL/m² and native T1 > 1119ms
- P = 0.017
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Native myocardial T1 and right ventricular size by CMR predict outcome in systemic sclerosis-associated pulmonary hypertension. Rheumatology (Oxford). Published 17 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →