Systemic sclerosis & Raynaud's
Fragmented QRS complex could predict all-cause mortality in patients with connective tissue disease–associated pulmonary arterial hypertension
Authors' conclusion
The presence of inferior fQRS and ST-T change could predict poor prognosis in CTD-PAH.
Study context
- Population
- Patients with CTD-PAH diagnosed by right heart catheterization114 discovery, 27 validation
- Participants
- 141 patients
- Exposure
- CTD-PAH with vs without fQRS and inferior ST-T change on 12-lead ECG
- Outcome
- All-cause death
Methodological detailsmulticentre, discovery and external validation cohorts, Kaplan-Meier survival analysis
- Multicentre
- Discovery and external validation cohorts
- Kaplan-Meier survival analysis
Main finding
As reported in the abstract
All-cause mortality (Kaplan-Meier)
- fQRS: P = 0.003
- Inferior ST-T change: P = 0.012
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| All-cause mortality in low- and intermediate-risk CTD-PAH (subgroup)Higher all-cause mortality with inferior ST-T change | P = 0.005 |
Right ventricular structure and function
- Inferior fQRS and ST-T change significantly associated with right ventricular dilatation and reduced right ventricular ejection fraction
External validation
- Prognostic value of fQRS and inferior ST-T change validated in external validation cohort
Original publication
Fragmented QRS complex could predict all-cause mortality in patients with connective tissue disease–associated pulmonary arterial hypertension. Rheumatology (Oxford). Published 7 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →