Systemic sclerosis & Raynaud's
Late‐Onset Scleroderma Renal Crisis Does Occur—A Multicenter Study
Authors' conclusion
Late-onset SRC was seen in up to 25% of patients with SRC, with a mean of 12 years after SSc diagnosis. Our findings reveal comparable clinical characteristics and outcomes between early- and late-onset SRC
Study context
- Population
- Patients diagnosed with scleroderma renal crisis (SRC) in systemic sclerosis (SSc), 1995–2018, three university-affiliated hospitals
- Participants
- 223 patients
- Exposure
- Late-onset vs early-onset scleroderma renal crisis
- Late onsetn = 54
- Early onsetn = 169reference
- Outcome
- Prevalence, clinical features and outcomes of late-onset SRC vs early-onset SRC
Methodological detailsmulticentre, three university-affiliated hospitals
- Multicentre
- Three university-affiliated hospitals
Main finding
As reported in the abstract
Prevalence of late- vs early-onset SRC
Observational data: associations, not effects.
Further findings
Male sex
| Outcome | Late onset | Early onset |
|---|---|---|
| Time from SSc diagnosis to SRC onset, late-onset SRC | mean 12.2 years | — not stated in the abstract |
— not stated in the abstract
Steroid exposure, late-onset vs early-onset SRC
- Steroid exposure more common in late-onset (late group 56%) than early-onset (early group 29%)
Autoantibody profile and outcomes
- No evidence of difference between early- and late-onset groups
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Late‐Onset Scleroderma Renal Crisis Does Occur—A Multicenter Study. Arthritis Care Res (Hoboken). Published 18 November 2025. doi:10.
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