Systemic sclerosis & Raynaud's
Treatment patterns and outcomes of scleroderma renal crisis in the international scleroderma renal crisis survey II – An inception cohort study
Authors' conclusion
Our data show that 1-year mortality and dialysis rates remain high in SRC and suggest that blood pressure should be controlled within 5-10 days after SRC presentation, as opposed to the expert-recommended 72 h, in order to maximize survival.
Study context
- Population
- Subjects with new-onset scleroderma renal crisis (SRC) in systemic sclerosis, identified by physicians with expertise in systemic sclerosis (SSc); outcomes collected from January 2020 to January 2022subjects with new-onset SRC identified, 83 with 1-year follow-up · with 1-year follow-up 83
- Participants
- 97 subjects
- Exposure
- Survival of subjects by the number of days to control blood pressure
- Outcome
- All-cause mortality
- Follow-up
- Within 12 months of SRC
Methodological details2-year web-based survey completed by international SSc experts, Cox proportional hazards models
- 2-year web-based survey completed by international SSc experts
- Cox proportional hazards models
Main finding
As reported in the abstract
One-year incidence mortality rate
39 per 100 person-years
Observational data: associations, not effects.
Further findings
Survival by time to control blood pressure
- Time to control blood pressure associated with best survival
- between 5-10 days after SRC presentation
Characteristics of the 83 with 1-year follow-up
- Median disease duration, of the 83 with 1-year follow-up
- 9 (interquartile range (IQR) 5-24) months
- Diffuse cutaneous disease, of the 83 with 1-year follow-up
- 63 (76%)
- RNA polymerase III autoantibodies, of the 83 with 1-year follow-up
- 38 (46%)
Anti-hypertensive treatment
- ACE inhibitors used (most frequently used anti-hypertensive)
- 98%
- Required ≥ three antihypertensives to control blood pressure
- 54%
Dialysis · one year
- Required dialysis
- 49%
- Remained on dialysis, of the 55 survivors at one year
- 25%
Time required to control blood pressure
- Median time
- 7 (IQR 3-10) days
Original publication
Treatment patterns and outcomes of scleroderma renal crisis in the international scleroderma renal crisis survey II – An inception cohort study. Semin Arthritis Rheum. Published 25 October 2026. doi:10.
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