Systemic sclerosis & Raynaud's
Outcomes of systemic sclerosis with overlapping myositis: a propensity score-matched cohort study
Authors' conclusion
Overlapping myositis in SSc is associated with an increased risk of cardiac involvement and a shift in the cause-of-death profile away from ILD, without a detectable difference in overall survival over the observed median 21-month follow-up. Systematic cardiac surveillance is needed in these patients.
Study context
- Population
- Systemic sclerosis (SSc) patients (2013 ACR/EULAR criteria) at a single centre, with and without overlapping myositis92 matched pairs analysed, from 880 SSc patients
- Participants
- 184 patients
- Exposure
- SSc with overlapping myositis vs matched SSc without myositis
- MYOSITISn = 92
- NON-MYOSITISn = 92
- Outcome
- Myositis among SSc patients
Methodological detailssingle centre, standard and Firth penalized logistic regression, Cox regression, Benjamini-Hochberg adjusted P-values
- Single centre
- Standard and Firth penalized logistic regression
- Cox regression
- Benjamini-Hochberg adjusted P-values
Main finding
As reported in the abstract
Patients with myositis, of 880
92
10.4%
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | P value | |
|---|---|---|---|
| Cardiac involvementMyositis independently predicted cardiac involvement | standard aOR 19.99 (95% CI 2.19–182.26) | P = 0.008 | |
| Cardiac involvementMyositis independently predicted cardiac involvement | Firth OR 12.84 (95% CI 2.31–98.47) | P = 0.006 | |
| 0.050.21520Ratio (log scale) |
Anti-Scl70 · less common in myositis
P = 0.009
Overall mortality · did not differ
P = 0.620
| Outcome | MYOSITIS | NON-MYOSITIS | P value |
|---|---|---|---|
| Cause of death | cardiac failure caused 25% of deaths; no ILD-related deaths | ILD caused 33.3% of deaths | Fisher’s P = 0.229 |
Cardiac involvement, per 10 points higher mRSS
- aOR per 10 points mRSS
- 2.34, P = 0.006
Mortality by cardiac involvement
- Cardiac involvement, aHR for mortality, independent of myositis
- 8.09 (1.36-48.26), P = 0.022
Original publication
Outcomes of systemic sclerosis with overlapping myositis: a propensity score-matched cohort study. Rheumatology (Oxford). Published 16 October 2026. doi:10.
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