Systemic sclerosis & Raynaud's
The Role of the Pulmonary Microenvironment in Driving Transition From Systemic Sclerosis to Systemic Sclerosis–Associated Interstitial Lung Disease
Authors' conclusion
Due to the limited number of studies, we were unable to perform a metaanalysis on mediators between SSc and SSc-ILD, highlighting the need for further studies. However, our review strongly highlights the involvement of the pulmonary epithelium in SSc-ILD, contributing to positive feedback between injured epithelial cells and fibroblast activation/fibrosis.
Study context
- Population
- Adult patients with systemic sclerosis (SSc); publications 2000–2024 in Web of Science and PubMed20 publications included
- Comparison
- BAL fluid soluble mediators in SSc-ILD vs SSc only
- Outcome
- Soluble mediators in bronchoalveolar lavage fluid differentiating SSc-ILD from SSc only
Methodological detailspreregistered study protocol, functional pathway enrichment (STRING-DB/G:Profiler)
- Preregistered study protocol
- Functional pathway enrichment (STRING-DB/G:Profiler)
Pooled result
As reported in the abstract
Soluble mediators in bronchoalveolar lavage fluid
Different mediators identified
30
Mediators available for SSc vs SSc-ILD comparison
17
Original publication
The Role of the Pulmonary Microenvironment in Driving Transition From Systemic Sclerosis to Systemic Sclerosis–Associated Interstitial Lung Disease. J Rheumatol. Published 15 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →