Systemic sclerosis & Raynaud's
Haematological malignancies in systemic sclerosis: a population-based nationwide register study
Main finding · Haematological malignanciesResult — go to the resultHazard ratio 2.2 95% CI 1.4–3.1Authors' conclusion
Individuals with SSc are afflicted by an increased risk of haematological malignancies, especially B-cell malignancies. The risk is highest in men. Myeloid malignancies tend to present closer to SSc diagnosis than lymphoid malignancies.
Study context
- Population
- Swedish residents with systemic sclerosis (SSc) diagnosed 2004–2019 and matched general population comparators11,480 and 131,021 person-years
- Participants
- 1,720 vs 16,983
- Exposure
- SSc vs matched general population comparators without SSc
- SScn = 1,720
- Comparatorsn = 16,983reference
- Outcome
- Haematological malignancies
Methodological detailsmatched general population comparators, Poisson regression, flexible parametric models
- Matched general population comparators
- Poisson regression
- Flexible parametric models
Main finding
As reported in the abstract
Hazard ratio
2.2
95% CI 1.4–3.1
SScvs Comparators
HR 2.2 (95% CI 1.4–3.1)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| B-cell malignancies | 3.0 (1.7–4.8) | |
| 0.20.5125Hazard ratio (log scale) |
| Outcome | Myeloid malignancies | Lymphoid malignancies |
|---|---|---|
| Time from SSc diagnosis to malignancy presentation | median 0.1 (IQR 8.2) years after SSc diagnosis | median 3.1 (IQR 9.5) |
Haematological malignancies by sex and age (subgroups)
- The incidence rate and the HR were highest in men
- SSc over-representation most evident in individuals aged 18-49 years at SSc diagnosis
Original publication
Haematological malignancies in systemic sclerosis: a population-based nationwide register study. RMD Open. Published 11 November 2025. doi:10.
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