Systemic sclerosis & Raynaud's
Pregnancy Outcomes in Women With Systemic Sclerosis Before and/or After Diagnosis and by Parity: A Swedish Population‐Based Cohort Study
Authors' conclusion
Contemporary women with SSc displayed markedly increased risks of several APOs after SSc diagnosis; the risks of some APOs were already increased before diagnosis, particularly within three years.
Study context
- Population
- Pregnancies with births in women with systemic sclerosis (SSc) and general-population comparator women, Swedish Medical Birth Register, 1998–2021pregnancies
- Exposure
- Pregnancies in women with SSc (after or before diagnosis) vs comparator women from the general population
- Post-SScn = 94
- Pre-SScn = 39
- Pre-SScn = 839
- Outcome
- Adverse pregnancy outcomes (APOs)
Methodological detailsnationwide, Swedish Medical Birth Register, regression models
- Nationwide
- Swedish Medical Birth Register
- Regression models
Main finding
As reported in the abstract
APOs in post-SSc pregnancies
Estimate (95% CI)
Post-SScvs Comparator
RR (preeclampsia) 3.8(1.8–7.8)
Post-SScvs Comparator
RR (preterm birth) 3.3(1.8–6.1)
Post-SScvs Comparator
RR (cesarean delivery) 2.5(1.8–3.5)
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | |
|---|---|---|
| APOs in primiparous post-SSc women (subgroup)Post-SScvs ComparatorPrimiparous | RR (preeclampsia) 7.5 (95% CI 3.5–16.1) | |
| APOs in primiparous post-SSc women (subgroup)Post-SScvs ComparatorPrimiparous | RR (preterm birth) 5.1 (95% CI 2.5–10.5) | |
| 0.050.21520Ratio (log scale) |
Adverse pregnancy outcomes (APOs) in pre-SSc pregnancies
- Increased odds of APOs in pre-SSc pregnancies, with the highest estimates in the zero to three years' pre-SSc pregnancies
Original publication
Pregnancy Outcomes in Women With Systemic Sclerosis Before and/or After Diagnosis and by Parity: A Swedish Population‐Based Cohort Study. Arthritis Rheumatol. Published 22 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →