Systemic sclerosis & Raynaud's
Survival in Swedish patients with systemic sclerosis: a nationwide population-based matched cohort study
Authors' conclusion
Despite advances in understanding the disease and in diagnostic methods over the past decades, survival is still severely impacted in Swedish patients diagnosed with SSc between 2004 and 2015.
Study context
- Population
- All patients with incident SSc in Sweden diagnosed 2004–2015 and matched general population comparators; followed to end of 2016matched cohort
- Participants
- 1,139 vs 5,613
- Exposure
- Incident SSc vs matched general population comparators
- SScn = 1,139
- Comparatorsn = 5,613reference
- Outcome
- All-cause survival
Methodological detailsmatched 1:5 on sex, birth year and residential area, flexible parametric models, Kaplan-Meier
- Matched 1:5 on sex, birth year and residential area
- Flexible parametric models
- Kaplan-Meier
Main finding
As reported in the abstract
5-year survival
10-year survival
- SSc vs Comparators: P < 0.0001 — survival comparison
Observational data: associations, not effects.
Further findings
Per 1000 person-years
| Outcome | SSc | Comparators | HR (95% CI) | |
|---|---|---|---|---|
| Mortality rate and HRAt end of first year of follow-up | 42.1 | 15.8 | 3.7 (2.9–4.7) | |
| Mortality rate and HRAt end of follow-up period | 2.0 (1.4–2.8) | |||
| 0.20.5125Hazard ratio (log scale) |
Events
| Outcome | SSc | Comparators |
|---|---|---|
| Deaths during follow-up · median follow-up 5.0 years (SSc) and 6.0 years (comparators) | 268 | 554 |
Original publication
Survival in Swedish patients with systemic sclerosis: a nationwide population-based matched cohort study. Rheumatology (Oxford). Published 19 August 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →