Systemic sclerosis & Raynaud's
Arrhythmia in patients with systemic sclerosis: incidence, risk factors and impact on mortality in a Swedish register-based study
Main finding · Incidence of arrhythmia, per 10 000 person yearsResult — go to the resultIncidence rate ratio 2.1 95% CI 1.8–2.5Authors' conclusion
SSc is associated with higher incidence of cardiac arrhythmia compared with general population. Arrhythmia seems to be an early manifestation of SSc and is associated with higher mortality.
Study context
- Population
- Patients with incident systemic sclerosis (SSc) 2004–2019 and matched general population comparators, nationwide Swedish registersmatched cohort
- Participants
- 1,565 vs 16,009
- Exposure
- Incident SSc vs matched general population comparators
- SScn = 1,565
- Comparatorsn = 16,009reference
- Outcome
- Incident arrhythmia
Methodological detailsnationwide Swedish registers, matched general population comparators (1:10), flexible parametric models, Cox regression
- Nationwide Swedish registers
- Matched general population comparators (1:10)
- Flexible parametric models
- Cox regression
Main finding
Incidence of arrhythmia, per 10 000 person years
Incidence rate ratio
2.1
95% CI 1.8–2.5
By group
SScvs Comparators
IRR 2.1 (95% CI 1.8–2.5)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Arrhythmia in the first year of follow-up (greatest hazard difference) | 3.0 (2.3–3.8) | |
| 0.20.5125Hazard ratio (log scale) |
Arrhythmia subtypes
- AF and flutter were the most common arrhythmia subtypes
Risk factors for arrhythmia in SSc
- Male sex, index age and PAH were significant risk factors
Mortality associated with incident arrhythmia
- Incident arrhythmia significantly associated with mortality, HR
- 2.2 (95% CI 1.6 to 3.0)
Original publication
Arrhythmia in patients with systemic sclerosis: incidence, risk factors and impact on mortality in a Swedish register-based study. RMD Open. Published 20 August 2024. doi:10.
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