Systemic sclerosis & Raynaud's
Evaluation of changes in cardiac longitudinal strain rate in patients with systemic sclerosis undergoing iloprost treatment: an observational study
Authors' conclusion
Iloprost administration improved GLS, suggesting that the increase of myocardial perfusion allowed, at least in part, a correction of left ventricular systolic dysfunction.
Study context
- Population
- Consecutive SSc patients (age 54 ± 11 years; 12 females) treated with Iloprost for presence/history of digital ulcers12 females
- Participants
- 15 patients
- Exposure
- Global longitudinal strain (GLS) after vs before a 6-h intravenous iloprost infusion
- Before Iloprostn = 15reference
- After Iloprostn = 15
- Outcome
- Mean GLS (echocardiography)
- Follow-up
- End of the 6-h infusion session
Methodological detailsbefore–after (pre/post infusion), consecutive patients
- Before–after (pre/post infusion)
- Consecutive patients
Main finding
As reported in the abstract
Mean GLS
Before Iloprost
−13.5
mean · SD 2.5
After Iloprost
−15
mean · SD 3.3
P = 0.011
Observational data: associations, not effects.
Further findings
Mean
| Outcome | Before Iloprost | After Iloprost | P value |
|---|---|---|---|
| GLS, four-chamber view · end of the 6-h infusion sessionHighly significant improvement · best quality view for GLS analysis | −13.4 (SD 2.2) | −15.6 (SD 3) | P = 0.001 |
Correlation of GLS improvement with SSc parameters
- Degree of GLS improvement did not correlate with any SSc parameters
Original publication
Evaluation of changes in cardiac longitudinal strain rate in patients with systemic sclerosis undergoing iloprost treatment: an observational study. Rheumatology (Oxford). Published 16 August 2024. doi:10.
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