Systemic sclerosis & Raynaud's
Domains and outcome measures for the assessment of cardiac involvement in juvenile systemic sclerosis: a scoping literature review
Authors' conclusion
This scoping review revealed significant heterogeneity in outcome measures used to assess cardiac involvement in SSc, limiting comparability across studies.
Study context
- Population
- Studies assessing cardiac involvement in juvenile and adult SSc with at least one outcome measure evaluated longitudinally; PubMed, Embase, Web of Science and CENTRAL (1994–2026)studies included
- Participants
- 57 studies
- Outcome
- Outcome measures for cardiac involvement in SSc
Methodological detailsPRISMA-ScR guidelines, part of the IJOG initiative
- PRISMA-ScR guidelines
- Part of the IJOG initiative
Main finding
As reported in the abstract
- Cardiac-domain studies identified
- 3,858
- Studies meeting inclusion criteria (majority prospective and single centre)
- 57
- Cardiac features identified
- 6
- Categories of outcome measures (majority clinician reported outcomes)
- 7
- Standard echocardiography (most common), studies
- 46
- Cardiac biomarkers, studies
- 27
- Right heart catheterisation, studies
- 25
- Paediatric studies (standard echocardiography, cardiac biomarkers, speckle-tracking echocardiography (STE))
- 3
- Children in paediatric studies
- 38
Original publication
Domains and outcome measures for the assessment of cardiac involvement in juvenile systemic sclerosis: a scoping literature review. Clin Exp Rheumatol. Published 4 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →