Systemic sclerosis & Raynaud's
Domains and outcome measures for the assessment of digital vasculopathy and Raynaud's phenomenon in adult and juvenile systemic sclerosis: a scoping literature review
Authors' conclusion
Outcome measures for digital vasculopathy in SSc are heterogeneous and derived almost entirely from adult studies, with no paediatric-specific validation.
Study context
- Population
- Prospective studies reporting outcomes in digital vasculopathy domains (digital ulcers (DU), Raynaud's phenomenon (RP), microvascular involvement, telangiectasia) in adult and juvenile systemic sclerosis (SSc); Medline, Embase, Web of Science and CENTRAL, 1994–2024108 studies included
- Participants
- 108 studies
- Outcome
- Outcome measures for digital vasculopathy in SSc and jSSc
Methodological detailsPRISMA-ScR guidelines
- PRISMA-ScR guidelines
Main finding
As reported in the abstract
- Records screened
- 46,002
- Studies included
- 108
- Studies involving adults only
- 105 (97.2%)
- Distinct outcome measures identified
- 50
- Clinician-reported outcomes (ClinROs)
- 35
- Patient-reported outcomes (PROs)
- 15
- DU domain: ClinROs (most frequently used as primary trial endpoints)
- 12
- DU domain: PROs
- 5
- RP domain: ClinROs
- 1
- RP domain: PROs (predominated as primary outcomes)
- 9
- Microvascular domain: ClinROs (instrumental measures used as primary endpoints); no PROs
- 16
- Telangiectasia domain: ClinROs (rarely used in trials)
- 6
- Telangiectasia domain: PROs
- 1
- Studies including paediatric patients
- 3
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Domains and outcome measures for the assessment of digital vasculopathy and Raynaud's phenomenon in adult and juvenile systemic sclerosis: a scoping literature review. Clin Exp Rheumatol. Published 19 August 2026. doi:10.
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