Systemic sclerosis & Raynaud's
Domain reporting in Systemic Sclerosis-Related Digital Ulcers: An OMERACT Scoping Review
Authors' conclusion
This scoping review identified a broad range of disease-related domains used to study SSc-DUs. There is significant heterogeneity in these domains.
Study context
- Population
- Studies of systemic sclerosis (SSc)-associated digital ulcers (EMBASE, MEDLINE, Cochrane Library; English, 1947 onwards; ≥15 participants for imaging and ≥25 for questionnaire-based studies)40 studies included
- Outcome
- Outcome domains used in studies of SSc-associated DUs
Methodological detailsOMERACT
- OMERACT
Main finding
As reported in the abstract
Domains used in SSc-DU studies (number of studies)
- Count/number of digital ulcers (DUs)
- 23
- Improvement in DUs
- 20
- Functional impact of DUs (25% of studies)
- 10
- Complications of DUs
- 7
- Pain
- 6
- Health-related quality of life
- 4
- Microvascular assessment/pathophysiology
- 4
- Global assessment of DUs
- 2
- Histopathology
- 1
Further findings
Study designs and interventions (number of studies)
- RCTs
- 13
- Prospective observational studies
- 12
- Retrospective observational studies
- 8
- Oral or intravenous drugs
- 25
- Topical/local treatments
- 5
- Surgical interventions
- 2
- 4869 manuscripts identified
Original publication
Domain reporting in Systemic Sclerosis-Related Digital Ulcers: An OMERACT Scoping Review. Semin Arthritis Rheum. Published 5 May 2023. doi:10.
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