Systemic sclerosis & Raynaud's
Juvenile- and adult-onset systemic sclerosis: similarities and differences in early disease patterns: a scoping review
Authors' conclusion
Early jSSc disease shares many similarities with, but also several differences from, early aSSc disease.
Study context
- Population
- Studies reporting clinical features of juvenile systemic sclerosis (jSSc) or aSSc, 41 countries39 studies
- Comparison
- Juvenile SSc vs adult SSc, early disease patterns
- Outcome
- Early disease clinical features
Methodological detailssystematic search of PubMed, Embase, MEDLINE and CENTRAL (January 1946-April 2026), stratified by disease duration: early (≤3 years) and late (≥5 years)
- Systematic search of PubMed, Embase, MEDLINE and CENTRAL (January 1946-April 2026)
- Stratified by disease duration: early (≤3 years) and late (≥5 years)
Main finding
As reported in the abstract
- Diffuse cutaneous disease, jSSc vs aSSc
- ≈70% vs. ≈41%
- Myositis, jSSc vs aSSc
- 33% vs. 5%
- Arthritis, jSSc vs aSSc
- 32.6% vs. 18%
- Digital ulcers, jSSc vs aSSc
- 51% vs. 20%
- Scleroderma renal crisis in early disease, jSSc vs aSSc
- 0% vs. 6%
Further findings
Crude mortality
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Juvenile- and adult-onset systemic sclerosis: similarities and differences in early disease patterns: a scoping review. Clin Exp Rheumatol. Published 19 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →