Systemic sclerosis & Raynaud's
Outcome measures for cutaneous and musculoskeletal involvement in juvenile systemic sclerosis: a scoping literature review
Authors' conclusion
Outcome measures for skin and musculoskeletal involvement in SSc are heterogeneous and derived almost exclusively from adult studies.
Study context
- Population
- Longitudinal studies evaluating skin and musculoskeletal outcome measures in SSc, incl. juvenile SSc
- Participants
- 108 studies
- Outcome
- Outcome measures used to assess cutaneous and musculoskeletal involvement in SSc
Methodological detailsPRISMA-ScR guidelines, PubMed, Embase, Web of Science and CENTRAL searched (1994-2026)
- PRISMA-ScR guidelines
- PubMed, Embase, Web of Science and CENTRAL searched (1994-2026)
Main finding
As reported in the abstract
Outcome measures identified
- Studies including adults only
- 106 (98.1%)
- Studies including only juvenile systemic sclerosis (jSSc) patients
- 2 (n=13)
- Distinct outcome measures
- 35
- Clinician-reported outcomes (of which 6 imaging measures)
- 23
- Patient-reported outcomes
- 9
- Performance outcomes
- 2
- Biomarker
- 1
- Studies evaluating hand involvement (most frequent domain)
- 54
- Studies evaluating overall function
- 51
- Studies evaluating mouth
- 24
- Studies evaluating joints/bone/tendon
- 18
- Studies evaluating muscle
- 8
- Studies evaluating skin
- 8
Original publication
Outcome measures for cutaneous and musculoskeletal involvement in juvenile systemic sclerosis: a scoping literature review. Clin Exp Rheumatol. Published 19 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →