Systemic sclerosis & Raynaud's
Induction of type I and III interferons by viral and endogenous stimuli in systemic sclerosis
Authors' conclusion
Leucocytes from SSc patients produce type I and III IFNs in response to a broad range of TLR stimuli.
Study context
- Population
- Patients with systemic sclerosis (SSc) and healthy individuals; Peripheral blood mononuclear cells (PBMCs) stimulated with RNA-IC (TLR7), ORN8L (TLR8) or inactivated herpes simplex virus (HSV) (TLR9)
- Participants
- 45 vs 47
- Comparison
- SSc patients vs healthy controls
- SScn = 45
- Healthy controlsn = 47reference
- Outcome
- Type I and III IFN (IFN-α, -β, -λ1, -λ2) responses to TLR7/8/9 stimulation
Methodological detailsex vivo TLR7/8/9 stimulation of PBMCs, monocyte-depleted PBMCs and monocytes
- Ex vivo TLR7/8/9 stimulation of PBMCs, monocyte-depleted PBMCs and monocytes
Main finding
As reported in the abstract
IFN production after Toll-like receptor (TLR) stimulation
- SSc PBMCs produced less interferon (IFN)-α than controls via TLR9
- p < 0.02
Further findings
IFN-β in monocytes after TLR9 activation
P = 0.041
Original publication
Induction of type I and III interferons by viral and endogenous stimuli in systemic sclerosis. Scand J Rheumatol. Published 18 August 2026. doi:10.
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