Systemic sclerosis & Raynaud's
Autoantibodies and Relapse of Systemic Sclerosis After Autologous Hematopoietic Cell Transplantation
Main finding · CIR by pre-HCT ARA (univariate)Result — go to the resultHazard ratio 0.21Authors' conclusion
Positive ARA pre-HCT is associated with reduced relapse risk, and post-HCT autoantibodies do not appear to be associated with relapse risk.
Study context
- Population
- Consecutive evaluable patients with systemic sclerosis (SSc) who underwent autologous hematopoietic cell transplantation (HCT) at a single center, followed for a median of 33 months16 (42%) relapsed
- Participants
- 38 patients
- Exposure
- Autoantibody-positive vs autoantibody-negative patients (pre-HCT); patients with vs without relapse (post-HCT autoantibody trajectory)
- Outcome
- Cumulative incidence of relapse by pre- or post-HCT serum levels of SSc-related autoantibodies
Methodological detailssingle-centre, consecutive patients, Autoantibody levels determined by immunoassays
- Single-centre
- Consecutive patients
- Autoantibody levels determined by immunoassays
Main finding
CIR by pre-HCT ARA (univariate)
Hazard ratio
0.21
P = 0.04
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR | P value |
|---|---|---|
| CIR by pre-HCT anti-Ro52, univariateAnti-Ro52 positive vs Anti-Ro52 negative · higher, not statistically significant | 2.90 | P = 0.053 |
| Relapse by pre-HCT Ro52, bivariate (adjusted for older age)Not associated with relapse | 2.21 | P = 0.16 |
Cumulative incidence of relapse (CIR) by pre-HCT antitopoisomerase antibody (ATA) (Scl-70) or antinuclear antibody (ANA)
- CIR similar in patients positive and negative for ATA or ANA
Post-HCT autoantibody level trajectory
- No significant difference between patients with vs without relapse
Original publication
Autoantibodies and Relapse of Systemic Sclerosis After Autologous Hematopoietic Cell Transplantation. J Rheumatol. Published 15 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →