Systemic sclerosis & Raynaud's
Clinical relevance of specific and non-specific autoantibodies in systemic sclerosis without overlap features
Authors' conclusion
Non-specific and IMID-associated autoantibodies are frequent in SSc patients without overlap but show limited clinical correlation.
Study context
- Population
- Consecutive systemic sclerosis (SSc) patients without overlap syndromes
- Participants
- 263 patients
- Outcome
- Frequency and clinical relevance of a broad autoantibody panel
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
As reported in the abstract
Autoantibody frequencies
- SSc-specific autoantibodies
- 88.2%
- Anti-Scl70
- 31.5%
- Anti-centromere
- 27%
- Anti-RNApol-III
- 8%
- Anti-Ro52
- 36.1%
- Rheumatoid factor (RF)
- 18.5%
Observational data: associations, not effects.
Further findings
Clinical associations of autoantibodies
- Anti-RNP and ILD (only significant clinical association)
- P = 0.007
Original publication
Clinical relevance of specific and non-specific autoantibodies in systemic sclerosis without overlap features. Semin Arthritis Rheum. Published 10 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →