Systemic sclerosis & Raynaud's
Detection of IgE-autoantibodies to nuclear antigens in patients with systemic sclerosis and analysis of their clinical relevance
Authors' conclusion
IgE-autoantibodies against CENP-A/B and topo-I occur in SSc underlining the concept that SSc may be a T helper cell type 2 mediated disease. IgE-anti-CENP-A-antibodies correlated with disease activity
Study context
- Population
- Patients with systemic sclerosis (SSc), CREST syndrome, other connective tissue disorders (CTD) and FM
- Participants
- 151 / 88 / 291 / 23
- Exposure
- SSc and CREST syndrome vs other CTD and FM controls
- SScn = 151
- CRESTn = 88
- Other CTDn = 291
- FMn = 23reference
- Outcome
- Prevalence and reactivity of IgE-autoantibodies to topoisomerase-I (topo-I) and CENP-A/B
Methodological detailsin-house ELISA with recombinant antigens
- In-house ELISA with recombinant antigens
Main finding
As reported in the abstract
Prevalence of IgE autoantibodies
| Group | Value | IgE-anti-CENP-A | IgE-anti-CENP-B | IgE-anti-topo-I |
|---|---|---|---|---|
| CREST | 67% | 67% | 77% | |
| SSc | 56% | 56% |
Value
CREST67%
SSc56%
IgE-anti-CENP-A
CREST67%
SSc— not stated in the abstract
IgE-anti-CENP-B
CREST77%
SSc— not stated in the abstract
IgE-anti-topo-I
CREST— not stated in the abstract
SSc56%
Observational data: associations, not effects.
Further findings
Clinical correlations in CREST syndrome
- IgE-anti-CENP-A (not CENP-B) significantly higher and more prevalent with skin ulcers, high median Rodnan skin score (mRSS) and >4 organ manifestations
- No correlation with blood eosinophil counts
Original publication
Detection of IgE-autoantibodies to nuclear antigens in patients with systemic sclerosis and analysis of their clinical relevance. Clin Exp Rheumatol. Published 6 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →