Associations between nailfold capillary aberrations and autoantibodies in children and adults with Raynaud’s phenomenon
Authors' conclusion
In contrast to adults, the association between nailfold capillary aberrations and ANA might be less pronounced in children.
Study context
- Population
- Consecutive children and adults with Raynaud's phenomenon (RP) and without previously known connective tissue disease
- Participants
- 113 vs 2,858
- Exposure
- Children vs adults with RP
- Childrenn = 113
- Adultsn = 2,858
- Outcome
- Associations between individual nailfold capillary aberrations and ANA
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
As reported in the abstract
Association between nailfold capillary aberrations and ANA titre ≥1:80
- Adults: individual nailfold capillary aberrations related to antinuclear antibodies (ANA) ≥1:80 (reduced capillary density, avascular fields, haemorrhages, oedema, ramifications, dilations and giant capillaries)
- each p<0.001
Observational data: associations, not effects.
Further findings
At least one nailfold capillary aberration
children vs adults p<0.05
ANA titre ≥1:80, ≥1:160 or ≥1:320 · adults: screened adults
ANA ≥1:80
ANA ≥1:160
ANA ≥1:320
Original publication
Associations between nailfold capillary aberrations and autoantibodies in children and adults with Raynaud’s phenomenon. RMD Open. Published 27 March 2023. doi:10.
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