Nailfold videocapillaroscopy in patients with deficiency of adenosine deaminase 2 (DADA2): a case-control study
Authors' conclusion
Only non-specific abnormalities were found, characterized mainly by capillaries' dilations, but in the absence of giant capillaries.
Study context
- Population
- DADA2 patients (mean age 18 ± 6 y) followed at the Children Gaslini Institute
- Participants
- 9 / 11 / 7
- Comparison
- DADA2 patients vs healthy controls and primary raynaud's phenomenon (RP) patients
- DADA2n = 9
- Healthy controls (HC)n = 11reference
- Primary RPn = 7reference
- Outcome
- Microvascular status by nailfold videocapillaroscopy (NVC) (EULAR SG Fast Track Algorithm: scleroderma vs non-scleroderma patterns)
Methodological detailsretrospective, age and sex matched, single-centre
- Retrospective
- Age and sex matched
- Single-centre
Main finding
As reported in the abstract
NVC findings in DADA2
| Group | Non-specific alterations | Capillaries with dilations | Abnormal shapes | Microhaemorrhages |
|---|---|---|---|---|
| DADA2 | all patients | 100% | 23% | 11% |
DADA2
Non-specific alterationsall patients
Capillaries with dilations100%
Abnormal shapes23%
Microhaemorrhages11%
- DADA2 vs Primary RP; HC: p values NS — no significant differences in the rate of each microvascular finding
Observational data: associations, not effects.
Original publication
Nailfold videocapillaroscopy in patients with deficiency of adenosine deaminase 2 (DADA2): a case-control study. Pediatr Rheumatol Online J. Published 23 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →