Risk factors for subsequent lupus nephritis in patients with juvenile-onset systemic lupus erythematosus: a retrospective cohort study
Authors' conclusion
Persistently high anti-dsDNA antibody and ESR levels during the follow-up period were risk factors for subsequent LN in patients with jSLE.
Study context
- Population
- Patients with jSLE without lupus nephritis (LN) at diagnosis, single tertiary medical centre, 2008–2018jSLE without initial LN
- Participants
- 48 patients
- Exposure
- jSLE patients who developed subsequent LN vs those who remained free of LN
- Group 1n = 20
- Group 2n = 28reference
- Outcome
- Development of subsequent LN
Methodological detailssingle tertiary medical centre, Cox regression, multivariable analysis
- Single tertiary medical centre
- Cox regression
- Multivariable analysis
Main finding
As reported in the abstract
Predictors of subsequent LN (multivariable Cox regression) · during follow-up
HR per 100 IU/ml increase in average anti-dsDNA antibody, 95% CI 1.055-1.573
1.29
Observational data: associations, not effects.
Further findings
Initial manifestations · at diagnosis
- No difference in percentage of initial manifestations except more discoid rashes in Group 2
Original publication
Risk factors for subsequent lupus nephritis in patients with juvenile-onset systemic lupus erythematosus: a retrospective cohort study. Pediatr Rheumatol Online J. Published 24 March 2023. doi:10.
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