Juvenile idiopathic arthritis patients with positive family history of autoimmune thyroid disease might benefit from serological screening: analysis of the international Pharmachild registry
Authors' conclusion
This is the first study to report independent predictor variables for symptomatic AITD in JIA. Female ANA positive JIA patients with positive family history are at increased risk of developing AITD
Study context
- Population
- Juvenile idiopathic arthritis (JIA) patients from the international Pharmachild registry
- Participants
- 8,965 patients
- Exposure
- JIA patients who developed autoimmune thyroid disease (AITD) vs those who did not
- AITDn = 96
- Outcome
- Prevalence and predictors of symptomatic AITD
- Follow-up
- Median observation period of 5.5 years
Methodological detailsinternational registry (Pharmachild), univariable and multivariable logistic regression
- International registry (Pharmachild)
- Univariable and multivariable logistic regression
Main finding
As reported in the abstract
Prevalence of AITD · median 5.5 years
AITD
1.1%
96
Observational data: associations, not effects.
Further findings
Independent predictors of AITD (multivariable)
| OR (95% CI) | ||
|---|---|---|
| Family history of AITD | 6.8 (4.1–11.1) | |
| Female sex | 2.2 (1.3–4.3) | |
| ANA positivity | 2.0 (1.3–3.2) | |
| Older age at JIA onset | 1.1 (1.1–1.2) | |
| 0.050.21520Odds ratio (log scale) |
Characteristics, AITD vs non-AITD
- Female
- 83.3% vs. 68.0%
- RF positive
- 10.0% vs. 4.3%
- ANA positive
- 55.7% vs. 41.5%
- Median age at JIA onset
- 7.8 years vs. 5.3 years
- Polyarthritis
- 40.6% vs. 30.4%
- Family history of AITD
- 27.5% vs. 4.8%
Number needed to screen (female ANA+ JIA with family history of AITD) · ±5.5 years
- Patients screened to detect one AITD case
- 16
Original publication
Juvenile idiopathic arthritis patients with positive family history of autoimmune thyroid disease might benefit from serological screening: analysis of the international Pharmachild registry. Pediatr Rheumatol Online J. Published 21 February 2023. doi:10.
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