Systemic sclerosis & Raynaud's
Gastric disease in systemic sclerosis: Spectrum, challenges, and insights from a systematic literature review
Authors' conclusion
Gastric disease in SSc is underrecognized, yet clinically significant.
Study context
- Population
- Studies of gastric manifestations in systemic sclerosis (SSc) (dysmotility, gastric antral vascular ectasia (GAVE), mucosal abnormalities, Helicobacter pylori)37 studies
- Outcome
- Gastric manifestations in SSc: prevalence
Methodological detailsPRISMA, registered with PROSPERO, MEDLINE, EMBASE and Web of Science searched (September 2024)
- PRISMA
- Registered with PROSPERO
- MEDLINE, EMBASE and Web of Science searched (September 2024)
Main finding
As reported in the abstract
Delayed gastric emptying
18-64 %
Bradygastria
12-70 %
GAVE prevalence
0 to 22.3 %
Helicobacter pylori prevalence
10-78 %
Further findings
GAVE associations with autoantibodies
- Negatively associated with anti-topoisomerase-I and variably associated with anti-RNA polymerase III antibodies
Helicobacter pylori detection by method
- Lower detection via biopsy or breath testing than serology
Objective findings vs patient-reported outcomes (PROs); gastric-specific mortality
- Associations between objective findings and PROs inconsistent and underexplored; data on gastric-specific mortality limited
Original publication
Gastric disease in systemic sclerosis: Spectrum, challenges, and insights from a systematic literature review. Semin Arthritis Rheum. Published 9 February 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →