Systemic sclerosis & Raynaud's
Proton pump inhibitor (PPI)-refractory gastroesophageal reflux disease (GERD) in SSc is driven by distinct oesophageal and gastric motility abnormalities
Authors' conclusion
PPI-refractory GERD is nearly universal in this SSc cohort and reflects heterogeneous, quantifiable abnormalities across the foregut, including impaired oesophageal clearance and increased reflux burden related to gastric retention.
Study context
- Population
- Adults with SSc undergoing ambulatory pH/MII monitoring on twice-daily PPI therapy (2021–25), single centre
- Participants
- 30 adults
- Exposure
- SSc patients with vs without oesophageal and gastric dysmotility
- Outcome
- Refractory GERD (Lyon 2.0 classification)
Methodological detailssingle-centre, 67% had PPI-refractory reflux symptoms; 33% undergoing pre-lung transplantation evaluation
- Single-centre
- 67% had PPI-refractory reflux symptoms; 33% undergoing pre-lung transplantation evaluation
Main finding
As reported in the abstract
- Refractory GERD
- 29/30 patients (97%)
- Conclusive evidence
- 53%
- Borderline evidence
- 43%
- Oesophageal dysmotility
- 80%
- Absent contractility (most common oesophageal dysmotility)
- 67%
- Gastric dysmotility
- 60.7%
Observational data: associations, not effects.
Further findings
| Outcome | Oesophageal dysmotilitymin | No oesophageal dysmotilitymin | Gastric dysmotility | No gastric dysmotility |
|---|---|---|---|---|
| Acid clearance timeSpread kind not named in abstract | 2.20 (range 1.15–3.75) | 1.15 (range 0.43–1.90) | — not stated in the abstract | — not stated in the abstract |
| Reflux episode durationSpread kind not named in abstract | 16.60 (range 4.38–40.63) | 1.95 (range 0.53–20.43) | — not stated in the abstract | — not stated in the abstract |
| Reflux episode burdenSpread kind not named in abstract | — not stated in the abstract | — not stated in the abstract | 51.00 (range 30.00–81.50) episodes/24 h | 25.00 (range 21.00–54.00) episodes/24 h |
— not stated in the abstract
Original publication
PPI-refractory GERD in SSc is driven by distinct oesophageal and gastric motility abnormalities. Rheumatology (Oxford). Published 20 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →