Systemic sclerosis & Raynaud's
Oesophageal dysmotility patterns are associated with distinct clinical phenotypes and prognosis in patients with systemic sclerosis
Authors' conclusion
We found that patients with AC and IEM have distinct clinical phenotypes, suggesting they are distinct entities. In patients with SSc, AC is independently associated with worse outcomes.
Study context
- Population
- Patients with SSc with detailed clinical and immunological data (84% female, mean age 45 ± 17 years)442 person-years follow-up
- Participants
- 201 patients
- Exposure
- Oesophageal motility patterns by high-resolution oesophageal manometry: Absent contractility (AC) vs IEM vs normal motility
- ACn = 86
- IEMn = 57
- Normal motilityn = 58
- Outcome
- Adverse outcomes:
- Death
- Lung transplantation
Methodological detailsKaplan-Meier and Cox regression analyses, Chicago 4.0 classification
- Kaplan-Meier and Cox regression analyses
- Chicago 4.0 classification
Main finding
As reported in the abstract
ACHazard ratio (95% CI)P value
Lung transplantation; adjusted for ILD and male sex
7.004(1.481–33.135)
P = 0.014SSc-related death; adjusted for dcSSc and ILD
3.472(1.071–10.969)
P = 0.038Observational data: associations, not effects.
Further findings
Clinical phenotypes by motility pattern
- AC associated with dcSSc, more severe digital ulcers, gastric vascular ectasia, anti-Ro60 antibodies and a late nailfold capillaroscopy pattern
- P < 0.05
- IEM linked to limited SSc, anti-centromere antibodies and an early/active nailfold pattern
Original publication
Oesophageal dysmotility patterns are associated with distinct clinical phenotypes and prognosis in patients with systemic sclerosis. Rheumatology (Oxford). Published 9 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →