Systemic sclerosis & Raynaud's
Decreasing prevalence and cumulative incidence of scleroderma renal crisis over time: associated factors identified from the RESCLE registry
Authors' conclusion
This study provides compelling evidence of a significant decline in SRC prevalence and cumulative incidence over time in SSc patients, particularly in definite-SSc patients and lcSSc patients.
Study context
- Population
- SSc patients in the RESCLE registry
- Participants
- 1,939 patients
- Exposure
- Historical cohort vs contemporary cohort
- Outcome
- Prevalence and incidence of SRC
Methodological detailshistorical vs contemporary cohort comparison
- Historical vs contemporary cohort comparison
Main finding
As reported in the abstract
SRC prevalence, overall SSc series
P = 0.001
- Scleroderma renal crisis (SRC) developed (overall prevalence rate 2.3%)
- 44
- First-year incidence, events per 100 person-years
- 2.09
Observational data: associations, not effects.
Further findings
SRC prevalence, definite-SSc cohort
P = 0.002
SRC prevalence, lcSSc
P = 0.013
SRC prevalence over time in dcSSc or by antibody profile
- No decrease over time in dcSSc or by antibody profile
SRC prevalence by cutaneous subset and antibody
- dcSSc
- 8.1%
- Anti-RNA polymerase III positive
- 12.0%
- Anti-topo I positive
- 4.3%
- lcSSc
- 0.9%
- Anti-centromere positive
- 0.7%
Factors independently associated with the contemporary cohort (CC)
- Older age at SSc diagnosis, more early and very early SSc subsets, tobacco exposure, more use of calcium channel blockers, renin-angiotensin-aldosterone system inhibitors, specific vasodilators and immunosuppressants
Original publication
Decreasing prevalence and cumulative incidence of scleroderma renal crisis over time: associated factors identified from the RESCLE registry. Rheumatology (Oxford). Published 7 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →