Systemic sclerosis & Raynaud's
Associations Between Patterns of Esophageal Dysmotility and Extra‐Intestinal Features in Patients With Systemic Sclerosis
Authors' conclusion
Among patients with SSc, AC is associated with a significantly more severe clinical phenotype. IEM may associate with a milder phenotype.
Study context
- Population
- Patients with systemic sclerosis (SSc) in the Johns Hopkins Scleroderma Center Research Registry who completed high-resolution esophageal manometry (HREM) as clinical care, 2011–2020SSc with HREM data
- Participants
- 95 patients
- Exposure
- Esophageal dysmotility patterns on HREM vs clinical phenotype
- ACn = 65
- IEMn = 9
- Normaln = 11
- Outcome
- Clinical features associated with AC
Methodological detailsregistry-based, single-centre
- Registry-based
- Single-centre
Main finding
As reported in the abstract
Diffuse cutaneous disease, AC vs comparator: 38.5% vs 10.0%; P < 0.01
38.5% versus 10.0%
More severe RP incl. digital pits, ulcers or gangrene, AC vs comparator: P = 0.02
56.9% versus 30.0%
Median DLCO, AC vs comparator: P = 0.03
50.6% versus 72.2%
Deaths with AC: P = 0.06
13 of 14
Observational data: associations, not effects.
Original publication
Associations Between Patterns of Esophageal Dysmotility and Extra‐Intestinal Features in Patients With Systemic Sclerosis. Arthritis Care Res (Hoboken). Published 17 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →